Journal of Biomaterials

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Investigation of the Effect of Silicon Concentration on Biocompatibility and Bioactivity of Spray Pyrolyzed Bioactive Glass

Received: 26 October 2023    Accepted: 22 November 2023    Published: 6 December 2023
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Abstract

Bioactive glass is a prominent biomaterial that can bind with both soft and hard tissues when in contact with body fluid. This study aims to find out how silicon concentration affects the cytotoxicity and bioactivity of bioactive glass. The 58S, 68S, and 76S BG particles were synthesized using a spray pyrolysis method. XRD, SEM, FTIR, and BET were used to examine the phase composition, morphology, chemical identity, and specific surface area of BG powders. The ability of the specimens to generate apatite on their surface after being soaked in the simulated body fluid (SBF) was determined using an in vitro test to measure their bioactivity. To evaluate the bioactivity of the BG powders, the in vitro apatite formation was investigated using XRD, FTIR, and SEM. Also, an in vitro cytotoxicity test was done using (MTT assay). A cell-growing environment was used to evaluate the in vitro cytotoxicity test based on different extraction concentrations of glass particles. The experimental results suggested that as silicon concentration in the BG increased, cell viability increased whereas bioactivity was reduced. Finally, the correlation between silicon content and cell viability and bioactivity was explored.

DOI 10.11648/j.jb.20230701.11
Published in Journal of Biomaterials (Volume 7, Issue 1, December 2023)
Page(s) 1-7
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Bioactive Glass, Bioactivity, Cytotoxicity, Silicon Concentration, Spray Pyrolysis

References
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    Chuni Aklilu, T., Gashaw Ewnete, B., Aboneh Mekuria, M., Aberra Tessema, A., Hadish, F., et al. (2023). Investigation of the Effect of Silicon Concentration on Biocompatibility and Bioactivity of Spray Pyrolyzed Bioactive Glass. Journal of Biomaterials, 7(1), 1-7. https://doi.org/10.11648/j.jb.20230701.11

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    ACS Style

    Chuni Aklilu, T.; Gashaw Ewnete, B.; Aboneh Mekuria, M.; Aberra Tessema, A.; Hadish, F., et al. Investigation of the Effect of Silicon Concentration on Biocompatibility and Bioactivity of Spray Pyrolyzed Bioactive Glass. J. Biomater. 2023, 7(1), 1-7. doi: 10.11648/j.jb.20230701.11

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    AMA Style

    Chuni Aklilu T, Gashaw Ewnete B, Aboneh Mekuria M, Aberra Tessema A, Hadish F, et al. Investigation of the Effect of Silicon Concentration on Biocompatibility and Bioactivity of Spray Pyrolyzed Bioactive Glass. J Biomater. 2023;7(1):1-7. doi: 10.11648/j.jb.20230701.11

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  • @article{10.11648/j.jb.20230701.11,
      author = {Tsion Chuni Aklilu and Bethelhem Gashaw Ewnete and Megersa Aboneh Mekuria and Aster Aberra Tessema and Filimon Hadish and Fetene Fufa Bakare},
      title = {Investigation of the Effect of Silicon Concentration on Biocompatibility and Bioactivity of Spray Pyrolyzed Bioactive Glass},
      journal = {Journal of Biomaterials},
      volume = {7},
      number = {1},
      pages = {1-7},
      doi = {10.11648/j.jb.20230701.11},
      url = {https://doi.org/10.11648/j.jb.20230701.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jb.20230701.11},
      abstract = {Bioactive glass is a prominent biomaterial that can bind with both soft and hard tissues when in contact with body fluid. This study aims to find out how silicon concentration affects the cytotoxicity and bioactivity of bioactive glass. The 58S, 68S, and 76S BG particles were synthesized using a spray pyrolysis method. XRD, SEM, FTIR, and BET were used to examine the phase composition, morphology, chemical identity, and specific surface area of BG powders. The ability of the specimens to generate apatite on their surface after being soaked in the simulated body fluid (SBF) was determined using an in vitro test to measure their bioactivity. To evaluate the bioactivity of the BG powders, the in vitro apatite formation was investigated using XRD, FTIR, and SEM. Also, an in vitro cytotoxicity test was done using (MTT assay). A cell-growing environment was used to evaluate the in vitro cytotoxicity test based on different extraction concentrations of glass particles. The experimental results suggested that as silicon concentration in the BG increased, cell viability increased whereas bioactivity was reduced. Finally, the correlation between silicon content and cell viability and bioactivity was explored.
    },
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Investigation of the Effect of Silicon Concentration on Biocompatibility and Bioactivity of Spray Pyrolyzed Bioactive Glass
    AU  - Tsion Chuni Aklilu
    AU  - Bethelhem Gashaw Ewnete
    AU  - Megersa Aboneh Mekuria
    AU  - Aster Aberra Tessema
    AU  - Filimon Hadish
    AU  - Fetene Fufa Bakare
    Y1  - 2023/12/06
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    N1  - https://doi.org/10.11648/j.jb.20230701.11
    DO  - 10.11648/j.jb.20230701.11
    T2  - Journal of Biomaterials
    JF  - Journal of Biomaterials
    JO  - Journal of Biomaterials
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    EP  - 7
    PB  - Science Publishing Group
    SN  - 2640-2629
    UR  - https://doi.org/10.11648/j.jb.20230701.11
    AB  - Bioactive glass is a prominent biomaterial that can bind with both soft and hard tissues when in contact with body fluid. This study aims to find out how silicon concentration affects the cytotoxicity and bioactivity of bioactive glass. The 58S, 68S, and 76S BG particles were synthesized using a spray pyrolysis method. XRD, SEM, FTIR, and BET were used to examine the phase composition, morphology, chemical identity, and specific surface area of BG powders. The ability of the specimens to generate apatite on their surface after being soaked in the simulated body fluid (SBF) was determined using an in vitro test to measure their bioactivity. To evaluate the bioactivity of the BG powders, the in vitro apatite formation was investigated using XRD, FTIR, and SEM. Also, an in vitro cytotoxicity test was done using (MTT assay). A cell-growing environment was used to evaluate the in vitro cytotoxicity test based on different extraction concentrations of glass particles. The experimental results suggested that as silicon concentration in the BG increased, cell viability increased whereas bioactivity was reduced. Finally, the correlation between silicon content and cell viability and bioactivity was explored.
    
    VL  - 7
    IS  - 1
    ER  - 

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Author Information
  • Department of Materials Science and Engineering, Adama Science and Technology University, Adama, Ethiopia

  • Department of Materials Science and Engineering, Adama Science and Technology University, Adama, Ethiopia

  • Animal Biotechnology Directorate, Bio and Emerging Institute Technology, Addis Ababa, Ethiopia

  • Department of Chemistry, Salale University, Oromia, Ethiopia

  • Department of Materials Science and Engineering, Adama Science and Technology University, Adama, Ethiopia

  • Department of Materials Science and Engineering, Adama Science and Technology University, Adama, Ethiopia; Department of Advanced Materials Science and Engineering Center of Excellence, Adama Science and Technology University, Adama, Ethiopia

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