Volume 1, Issue 2, December 2017, Page: 34-39
Studying the Optimum Conditions for the Synthesis the Derivatives of Salicylaldehyde with Halides Compounds
Joumaa Merza, Department of Chemistry, Faculty of Sciences, Al-Baath University, Homs, Syria
Ali Alasmi, Department of Chemistry, Faculty of Sciences, Al-Baath University, Homs, Syria
Received: Apr. 8, 2017;       Accepted: May 22, 2017;       Published: Jul. 13, 2017
DOI: 10.11648/j.jb.20170102.12      View  1536      Downloads  79
Abstract
Three Dialdehydes were synthesized by the reaction of Salicylaldehyde and many Aliphatic and Aromatic Halides. The optimal condition (Catalysts, Temperature, Time of Reaction and Effect of Solvents) to get a high selective compounds and high yields have been studied. The reactions were followed by using Thin Layer Chromatography (TLC). The synthesized compounds were purified and characterized by means of High Performance Liquid Chromatography (HPLC) and spectroscopy methods: Infrared Spectra (IR), 1 H-NMR, 13C-NMR.
Keywords
Salicylaldehyde, Heterogeneous Catalysts, Dialdehyde, Aliphatic and Aromatic Halides
To cite this article
Joumaa Merza, Ali Alasmi, Studying the Optimum Conditions for the Synthesis the Derivatives of Salicylaldehyde with Halides Compounds, Journal of Biomaterials. Vol. 1, No. 2, 2017, pp. 34-39. doi: 10.11648/j.jb.20170102.12
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Misbah. R, Imran. M, Arif. M, 2013, Synthesis, Characterization and in Vitro Antimicrobial Studies of Schiff-Bases Derived from Acetylacetone and Amino Acids and their Oxovanadium (IV) Complexes, Am J of Appl Chem, V. 4, P. 59-66.
[2]
Arif. M, Qurashi. M, Shad. M, 2011, Metal-based antibacterial agents: synthesis, characterization, and in vitro biological evaluation of cefixime-derived Schiff bases and their complexes with Zn(II), Cu(II), Ni(II), and Co(II), J of Coord Chem, V. 64, P. 1914-1930.
[3]
Min. W, Liu-Fang. W, Yi-Zhi. L, Qin-Xi. L, Zhi-Dong. X, 2001, Antitumour activity of transition metal complexes with the thiosemicarbazone derived from 3-acetylumbelliferone, Trans Metal Chem, V. 26, P. 307-310.
[4]
Abdullah. M, Salman. A, 2010, Synthesis and Anti-Bacterial Activities of Some Novel Schiff Bases Derived from Aminophenazone. Molecules, V. 15, P. 6850-6858.
[5]
Maji. M, Ghosh. S, Chattopadhyay. S, 1999, Studies on Ru(II) complexes of 4 (4- tolyl ) thiosemicarbazone of 2-acetylpyridine (LH). First synthesis and structural characterization of a Ru complex containing the imine (mpi). Crystal structure of [Ru (LH) (PPh3) 2Cl] Cl. CH2Cl2 and [Ru (LH) (PPh3) (mpi)] Cl2. CH2Cl2. 3H2O, J. Chem. Soc. Dalton Trans, P. 135-140.
[6]
Sengupta. P, Dinda. R, Ghosh. S, Sheldrick. W, 2003, Synthesis and characterization of some biologically active ruthenium (II) complexes of thiosemicarbazones of pyridine 2-aldehyde and thiophene 2-aldehyde involving some ring substituted 4-phenylthiosemicarbazides and 4-Cyclohexylthiosemicarbazide. Crystal Structure of Cis-[Ru (PPh3) 2 (L6H)2] (ClO4)2 2H2O [L6H = 4- (Cyclohexyl) Thiosemicarbazone of Pyridine 2-Aldehyde]. Polyhedron, V. 22, P. 447-453.
[7]
Christian. G, 1996, Analytical strategies for the measurement of lithium in biological samples, J Pharm Biomed Anal, V. 14, P. 899-908.
[8]
Ibrahim. U, Ismet. B, Turgut. K, 2006, Synthesis, complexation and antifungal, antibacterial activity studies of a new macrocyclic schiff base. J of Heterocyclic Chem, V. 43, P. 1679-1684.
[9]
Ariadni. Z, George. P, Antonios. H, 2016, Synthesis, structural, thermal characterization and interaction with calf-thymus DNA and albumins of cationic Ni(II) complexes with 2,2'-dipyridylamine and salicylaldehydes, Polyhedron, p. 1-33.
[10]
Eila. P, Markku. L and Hannu. E, 2011, Substituted Salicylaldehydes as Potential Antimicrobial Drugs: Minimal Inhibitory and Microbicidal Concentrations, Z. Naturforsch, V. 66, P. 571–580.
[11]
Mounika. K, Anupama. B, Pragathi. J and Gyanakumari. C, 2010, Synthesis¸ Characterization and Biological Activity of a Schiff Base Derived from 3-Ethoxy Salicylaldehyde and 2-Amino Benzoic acid and its Transition Metal Complexes, J. Sci. Res, V. 2, P. 513-524.
[12]
Michael. S, Jerry. M, 2007, MARCH’S ADVANCED ORGANIC CHEMISTRY, John Wiley & Sons, Inc, p. 1-2357.
[13]
Hongchuan. X, Liangning. Hu, Jianqiang. Yu, 2017, A green catalytic method for selective synthesis of iodophenols via aerobic oxyiodination under organic solvent-free conditions, Catalysis Communications, p. 1-18.
[14]
Selmi. B, GontierE, Ergan. F and Thomas. D, 1997, Enzymatic synthesis of tricaprylin in a solvent-free system: lipase regiospecificity as controlled by glycerol adsorption on silica gel, Biotechnology Techniques, V. 11, pp. 543–547.
[15]
Meenakshisundaram. S, Nikolaos. D, 2012, Designing bimetallic catalysts for a green and sustainable future, Chem. Soc. Rev, V. 41, P. 8099–8139.
[16]
Olayinka. B and Ibitola. B, 2004, Rationalization of the conflicting effects of hydrogen bond donor solvent on nucleophilic aromatic substitution reactions in non-polar aprotic solvent: reactions of phenyl 2, 4, 6-trinitrophenyl ether with primary and secondary amines in benzene–methanol mixtures, Tetrahedron, V. 60, P. 4645–4654.
[17]
Mikhail. K, Oleg. B, 2014, The mechanisms of nucleophilic substitution in 1-methyl-3, 4, 5-trinitropyrazole, Computational and Theoretical Chemistry, V. 1033, P. 31–42.
[18]
Henry. M, Adele. R, 2012, Impact of fluorine substituents on the rates of nucleophilic aliphatic substitution and b-elimination, Journal of Fluorine Chemistry, V. 135, P. 167–175.
[19]
Michele. A, Germani. R, 2013, Effects of temperature on micellar-assisted bimolecular reaction of methylnaphtalene-2-sulphonate with bromide and chloride ions, Journal of Colloid and Interface Science, V. 402, P. 165–172.
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